InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RYR3

Summary

InnateDB Protein

IDBP-364053.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RYR3

Protein Name

ryanodine receptor 3

Synonyms

RYR-3;

Species

Homo sapiens

Ensembl Protein

ENSP00000399610

InnateDB Gene

IDBG-5249 (RYR3)

Protein Structure

UniProt Annotation

Function

Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling. {ECO:0000250, ECO:0000269PubMed:12354756}.

Subcellular Localization

Sarcoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic. {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain, skeletal muscle, placenta and possibly liver and kidney. In brain, highest levels are found in the cerebellum, hippocampus, caudate nucleus and amygdala, with lower levels in the corpus callosum, substantia nigra and thalamus. {ECO:0000269PubMed:9395096, ECO:0000269PubMed:9607712}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005219	ryanodine-sensitive calcium-release channel activity
GO:0005262	calcium channel activity
GO:0005488	binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0015278	calcium-release channel activity

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0034220	ion transmembrane transport
GO:0051289	protein homotetramerization
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0071277	cellular response to calcium ion
GO:0071286	cellular response to magnesium ion
GO:0071313	cellular response to caffeine
GO:0071318	cellular response to ATP

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0033017	sarcoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000699 RIH (RyR and IP3R Homology) domain
IPR001870 B30.2/SPRY domain
IPR002048 EF-hand domain
IPR003032 Ryanodine receptor Ryr
IPR003877 SPRY domain
IPR005821 Ion transport domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009079 Four-helical cytokine-like, core
IPR009460 Ryanodine Receptor TM 4-6
IPR013333 Ryanodine receptor
IPR013662 RyR/IP3R Homology associated domain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016024 Armadillo-type fold
IPR016093 MIR motif

PFAM