Version 5.4
Homo sapiens Gene: ANKS1B
Summary
InnateDB Gene IDBG-52572.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANKS1B
Gene Name ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185046
Encoded Proteins
IDBP-52574
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-52578
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-52580
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-602762
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-595964
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-595799
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-596427
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-596979
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-595386
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-595985
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-597515
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-589643
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-811969
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-587429
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-588003
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-811972
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-811973
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-811976
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-811971
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-811978
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-811980
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-811981
ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-583854
ankyrin repeat and sterile alpha motif domain containing 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:98726457-99984654
Strand Reverse strand
Band q23.1
Transcripts
ENST00000329257 ENSP00000331381
ENST00000333732 ENSP00000331256
ENST00000341752 ENSP00000345510
ENST00000555119 ENSP00000452523
ENST00000549558 ENSP00000448993
ENST00000547776 ENSP00000449629
ENST00000551212
ENST00000547010 ENSP00000448512
ENST00000550693 ENSP00000447999
ENST00000549025 ENSP00000447312
ENST00000549493 ENSP00000448203
ENST00000547446 ENSP00000450015
ENST00000550778 ENSP00000448744
ENST00000547362 ENSP00000473277
ENST00000546568 ENSP00000448205
ENST00000546960 ENSP00000447839
ENST00000549315
ENST00000552407 ENSP00000473331
ENST00000549797 ENSP00000473300
ENST00000551613 ENSP00000473513
ENST00000551830
ENST00000546364 ENSP00000473522
ENST00000551560 ENSP00000473673
ENST00000552748 ENSP00000473434
ENST00000548447 ENSP00000473517
ENST00000552245
ENST00000557083
ENST00000552210
ENST00000546631
ENST00000550833
ENST00000550157
ENST00000549866 ENSP00000449894
ENST00000552232
ENST00000552472
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046875 ephrin receptor binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0014069 postsynaptic density
GO:0015030 Cajal body
GO:0030054 cell junction
GO:0043197 dendritic spine
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
null
View Gene Order
Cross-References
SwissProt Q7Z6G8
TrEMBL R4GN70
UniProt Splice Variant
Entrez Gene 56899
UniGene Hs.506458 Hs.549268 Hs.641720
RefSeq NM_001204067 NM_001204065 NM_001204066 NM_001204068 NM_001204069 NM_001204070 NM_001204079 NM_001204080 NM_001204081 NM_020140 NM_152788 NM_181670 XM_005269028 XM_005269029 XM_006719509 XM_006719510
HUGO HGNC:24600
OMIM 607815
CCDS CCDS55871 CCDS55864 CCDS55865 CCDS55866 CCDS55867 CCDS55868 CCDS55869 CCDS55870 CCDS55872
HPRD 07426
IMGT
EMBL AC008126 AC011248 AC021653 AC048330 AC069437 AC078916 AC079954 AC084374 AC117377 AC126616 AC141554 AC141555 AC141556 AF145204 AF164792 AK289768 AK294191 AK294994 AY281131 AY281132 AY283057 AY620824 AY753193 BC026313 BC068451 BC142669 BC150204
GenPept AAD33951 AAF80756 AAH26313 AAH68451 AAI42670 AAI50205 AAP37612 AAP37613 AAP38184 AAT39519 AAV28691 BAF82457 BAG57507 BAG58059
RNA Seq Atlas 56899

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca