Homo sapiens Gene: ANKS1B

Summary
InnateDB Gene IDBG-52572.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol ANKS1B
Gene Name ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1
Species Homo sapiens
Ensembl Gene ENSG00000185046
Encoded Proteins
IDBP-52574 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-52578 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-52580 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-52582 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-602762 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-595964 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-595799 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-596427 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-596979 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-595386 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-595985 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-597515 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-589643 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-587429 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-588003 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-598261 ankyrin repeat and sterile alpha motif domain containing 1B
IDBP-583854 ankyrin repeat and sterile alpha motif domain containing 1B
Entrez Gene
Summary This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12: 99120235-100378432
Strand Reverse strand
Band q23.1
Transcripts
ENST00000329257  ENSP00000331381
ENST00000333732  ENSP00000331256
ENST00000341752  ENSP00000345510
ENST00000332712  ENSP00000332683
ENST00000555119  ENSP00000452523
ENST00000546541 
ENST00000549558  ENSP00000448993
ENST00000547776  ENSP00000449629
ENST00000551212 
ENST00000547010  ENSP00000448512
ENST00000550693  ENSP00000447999
ENST00000549025  ENSP00000447312
ENST00000549493  ENSP00000448203
ENST00000547446  ENSP00000450015
ENST00000550778  ENSP00000448744
ENST00000547362 
ENST00000546568  ENSP00000448205
ENST00000546960  ENSP00000447839
ENST00000549315 
ENST00000552407 
ENST00000549797 
ENST00000551613 
ENST00000551830 
ENST00000546364 
ENST00000552769 
ENST00000551560 
ENST00000552748 
ENST00000548447 
ENST00000552245  ENSP00000447784
ENST00000557083 
ENST00000552210 
ENST00000546631 
ENST00000550833 
ENST00000550157 
ENST00000549866  ENSP00000449894
ENST00000552232 
ENST00000552472 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein‑Protein  12
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0005515 protein binding
GO:0046875 ephrin receptor binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0015030 Cajal body
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000096382 RBBH Low Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q7Z6G8 
TrEMBL B7Z9I9 F5GX70 F8VPM3 F8VR14 F8VVQ4 F8VZ47 F8VZR9 F8WC27 J3QSU0
UniProt Splice Variant
Entrez Gene 56899 
UniGene Hs.506458 Hs.549268 Hs.641720
RefSeq NM_001204066  NM_001204067  NM_001204068  NM_001204069  NM_001204070  NM_001204081  NM_020140  NM_152788  NM_181670 
HUGO 24600 
OMIM 607815
CCDS CCDS55864  CCDS55865  CCDS55866  CCDS55867  CCDS55868  CCDS55869  CCDS55870  CCDS55871  CCDS55872 
HPRD 07426
IMGT
EMBL AC008126 AC011248 AC021653 AC048330 AC069437 AC078916 AC079954 AC084374 AC117377 AC126616 AC141554 AC141555 AC141556 AF145204 AF164792 AK289768 AK315954 AY281131 AY281132 AY283057 AY620824 AY753193 BC026313 BC068451 BC142669 BC150204
GenPept AAD33951  AAF80756  AAH26313  AAH68451  AAI42670  AAI50205  AAP37612  AAP37613  AAP38184  AAT39519  AAV28691  BAF82457  BAH14325 
ImmGen ANKS1B (murine) 
RNA Seq Atlas 56899