InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANKS1B

Summary

InnateDB Protein

IDBP-587429.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANKS1B

Protein Name

ankyrin repeat and sterile alpha motif domain containing 1B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000448205

InnateDB Gene

IDBG-52572 (ANKS1B)

Protein Structure

UniProt Annotation

Function

Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. {ECO:0000250}.Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15004329, ECO:0000269PubMed:15347684, ECO:0000269PubMed:15862129, ECO:0000269PubMed:19666031}.Isoform 2: Nucleus.Isoform 3: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. Note=The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity). {ECO:0000250}.Isoform 4: Nucleus. Note=The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.Isoform 6: Nucleus.

Disease Associations

Tissue Specificity

Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines. {ECO:0000269PubMed:10490826, ECO:0000269PubMed:15347684}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

Cellular Component

GO:0005737	cytoplasm
GO:0014069	postsynaptic density
GO:0015030	Cajal body
GO:0030054	cell junction
GO:0043197	dendritic spine
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR006020 PTB/PI domain
IPR011510 Sterile alpha motif, type 2
IPR013625 Tensin phosphotyrosine-binding domain
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF00640
PF14719
PF07647
PF08416
PF00536

PRINTS

PIRSF

SMART

SM00454
SM00462

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7Z6G8