InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NR1H4

Summary

InnateDB Gene

IDBG-52872.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR1H4

Gene Name

nuclear receptor subfamily 1, group H, member 4

Synonyms

BAR; FXR; HRR-1; HRR1; RIP14

Species

Homo sapiens

Ensembl Gene

ENSG00000012504

Encoded Proteins

IDBP-52874

nuclear receptor subfamily 1, group H, member 4

IDBP-52876

nuclear receptor subfamily 1, group H, member 4

IDBP-244538

nuclear receptor subfamily 1, group H, member 4

IDBP-588009

nuclear receptor subfamily 1, group H, member 4

IDBP-585055

nuclear receptor subfamily 1, group H, member 4

IDBP-591340

nuclear receptor subfamily 1, group H, member 4

IDBP-597816

nuclear receptor subfamily 1, group H, member 4

IDBP-594644

nuclear receptor subfamily 1, group H, member 4

IDBP-586409

nuclear receptor subfamily 1, group H, member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19864602

NR1H4 is an essential component of a network of nuclear receptors that regulate intestinal innate immunity and homeostasis.

InnateDB Annotation from Orthologs

Summary

PMID 23372731

[Mus musculus] The bile acid sensor Nr1h4 (FXR) Is required for immune-regulatory activities of TLR9 in intestinal inflammation.

Entrez Gene

Summary

This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:100473708-100564413

Strand

Forward strand

Band

q23.1

Transcripts

ENST00000321046	ENSP00000315442
ENST00000188403	ENSP00000188403
ENST00000392986	ENSP00000376712
ENST00000548884	ENSP00000448506
ENST00000549996	ENSP00000448978
ENST00000546380	ENSP00000446760
ENST00000548621	ENSP00000446584
ENST00000551379	ENSP00000447149
ENST00000551184	ENSP00000446861

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	33 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0004872	receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004887	thyroid hormone receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0032052	bile acid binding
GO:0038181	bile acid receptor activity
GO:0042277	peptide binding
GO:0043565	sequence-specific DNA binding
GO:0046965	retinoid X receptor binding
GO:1902122	chenodeoxycholic acid binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001080	nitrogen catabolite activation of transcription from RNA polymerase II promoter
GO:0006109	regulation of carbohydrate metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0008206	bile acid metabolic process
GO:0009749	response to glucose
GO:0010467	gene expression
GO:0030522	intracellular receptor signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0034255	regulation of urea metabolic process
GO:0038185	intracellular bile acid receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048565	digestive tract development
GO:0070857	regulation of bile acid biosynthetic process
GO:0070858	negative regulation of bile acid biosynthetic process
GO:0071229	cellular response to acid
GO:0071417	cellular response to organonitrogen compound
GO:0090181	regulation of cholesterol metabolic process
GO:2000213	positive regulation of glutamate metabolic process
GO:2001250	positive regulation of ammonia assimilation cycle