InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR1H4

Summary

InnateDB Protein

IDBP-588009.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR1H4

Protein Name

nuclear receptor subfamily 1, group H, member 4

Synonyms

BAR; FXR; HRR-1; HRR1; RIP14;

Species

Homo sapiens

Ensembl Protein

ENSP00000448506

InnateDB Gene

IDBG-52872 (NR1H4)

Protein Structure

UniProt Annotation

Function

Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. {ECO:0000269PubMed:10334992, ECO:0000269PubMed:10334993, ECO:0000269PubMed:12718892, ECO:0000269PubMed:12815072, ECO:0000269PubMed:15471871, ECO:0000269PubMed:18621523, ECO:0000269PubMed:19410460, ECO:0000269PubMed:19586769}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	33 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004887	thyroid hormone receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0032052	bile acid binding
GO:0038181	bile acid receptor activity
GO:0043565	sequence-specific DNA binding
GO:1902122	chenodeoxycholic acid binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001080	nitrogen catabolite activation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0010467	gene expression
GO:0030522	intracellular receptor signaling pathway
GO:0034255	regulation of urea metabolic process
GO:0038185	intracellular bile acid receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070857	regulation of bile acid biosynthetic process
GO:0070858	negative regulation of bile acid biosynthetic process
GO:0071229	cellular response to acid
GO:0071417	cellular response to organonitrogen compound
GO:0090181	regulation of cholesterol metabolic process
GO:2000213	positive regulation of glutamate metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005719	nuclear euchromatin

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR001728 Thyroid hormone receptor
IPR003069 Ecdysteroid receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR00546
PR01283

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt