Version 5.4
Homo sapiens Gene: BCL11A
Summary
InnateDB Gene IDBG-52891.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL11A
Gene Name B-cell CLL/lymphoma 11A (zinc finger protein)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119866
Encoded Proteins
IDBP-52893
B-cell CLL/lymphoma 11A (zinc finger protein)
IDBP-52895
B-cell CLL/lymphoma 11A (zinc finger protein)
IDBP-52897
B-cell CLL/lymphoma 11A (zinc finger protein)
IDBP-52899
B-cell CLL/lymphoma 11A (zinc finger protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:60451167-60553567
Strand Reverse strand
Band p16.1
Transcripts
ENST00000356842 ENSP00000349300
ENST00000359629 ENSP00000352648
ENST00000358510 ENSP00000351307
ENST00000335712 ENSP00000338774
ENST00000409351
ENST00000489516
ENST00000479026
ENST00000492272
ENST00000477659
ENST00000489183
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 30 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0010629 negative regulation of gene expression
GO:0010976 positive regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0016925 protein sumoylation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030517 negative regulation of axon extension
GO:0032463 negative regulation of protein homooligomerization
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048671 negative regulation of collateral sprouting
GO:0048672 positive regulation of collateral sprouting
GO:0050773 regulation of dendrite development
GO:2000171 negative regulation of dendrite development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016604 nuclear body
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000000861
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.370549 Hs.600137 Hs.600805 Hs.628999
RefSeq NM_018014 NM_022893 NM_138559
HUGO
OMIM
CCDS CCDS1861 CCDS1862 CCDS46295
HPRD 05949
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca