InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCL11A

Summary

InnateDB Protein

IDBP-52899.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL11A

Protein Name

B-cell CLL/lymphoma 11A (zinc finger protein)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000338774

InnateDB Gene

IDBG-52891 (BCL11A)

Protein Structure

UniProt Annotation

Function

Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11161790}. Nucleus {ECO:0000269PubMed:11161790}. Note=Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity). {ECO:0000250}.

Disease Associations

Note=Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and amplification.

Tissue Specificity

Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development. {ECO:0000269PubMed:11161790, ECO:0000269PubMed:11719382}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	30 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0010629	negative regulation of gene expression
GO:0010976	positive regulation of neuron projection development
GO:0010977	negative regulation of neuron projection development
GO:0016925	protein sumoylation
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0030517	negative regulation of axon extension
GO:0032463	negative regulation of protein homooligomerization
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048671	negative regulation of collateral sprouting
GO:0048672	positive regulation of collateral sprouting
GO:0050773	regulation of dendrite development
GO:2000171	negative regulation of dendrite development