InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: OTUB1

Summary

InnateDB Gene

IDBG-52992.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OTUB1

Gene Name

OTU domain, ubiquitin aldehyde binding 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000167770

Encoded Proteins

IDBP-377017

OTU domain, ubiquitin aldehyde binding 1

IDBP-377022

OTU domain, ubiquitin aldehyde binding 1

IDBP-588161

OTU domain, ubiquitin aldehyde binding 1

IDBP-587215

OTU domain, ubiquitin aldehyde binding 1

IDBP-598375

OTU domain, ubiquitin aldehyde binding 1

IDBP-585348

OTU domain, ubiquitin aldehyde binding 1

IDBP-592881

OTU domain, ubiquitin aldehyde binding 1

IDBP-600044

OTU domain, ubiquitin aldehyde binding 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19996094

OTUB1 and OTUB2 negatively regulate virus-triggered type I interferon (IFN) induction and cellular antiviral response by deubiquitinating TRAF3 and -6.

Entrez Gene

Summary

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:63985853-64001811

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000301453
ENST00000447683
ENST00000422031	ENSP00000416973
ENST00000428192	ENSP00000402551
ENST00000541478	ENSP00000439142
ENST00000535715	ENSP00000440211
ENST00000538426	ENSP00000444357
ENST00000543004	ENSP00000437453
ENST00000536443
ENST00000543988	ENSP00000441328
ENST00000535140	ENSP00000444968
ENST00000536943

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 103 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	103 [view]
Protein-Protein	102 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008242	omega peptidase activity
GO:0019784	NEDD8-specific protease activity
GO:0031625	ubiquitin protein ligase binding
GO:0043130	ubiquitin binding

Biological Process

GO:0002376	immune system process
GO:0006281	DNA repair
GO:0006508	proteolysis
GO:0006974	cellular response to DNA damage stimulus
GO:0019538	protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0071108	protein K48-linked deubiquitination
GO:1901315	negative regulation of histone H2A K63-linked ubiquitination
GO:2000780	negative regulation of double-strand break repair

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024767

View Gene Order

ENSBTAG00000003967

Not yet available

Cross-References

SwissProt

Q96FW1

TrEMBL

F5GYJ8 F5GYN4 F5H3F0 F5H4F3 F5H6Q1 J3KR44

UniProt Splice Variant

Entrez Gene

55611

UniGene

Hs.473788

RefSeq

NM_017670

HUGO

HGNC:23077

OMIM

608337

CCDS

CCDS8055

HPRD

IMGT

EMBL

AF161381 AK000120 AP000721 AY177200 BC007519 BC010368 BC107701

GenPept

AAF28941 AAH07519 AAH10368 AAI07702 AAO27702 BAA90956

RNA Seq Atlas

101927673 55611