Version 5.4
Mus musculus Gene: Otub1
Summary
InnateDB Gene IDBG-138319.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Otub1
Gene Name OTU domain, ubiquitin aldehyde binding 1
Synonyms AI850305
Species Mus musculus
Ensembl Gene ENSMUSG00000024767
Encoded Proteins
IDBP-138321
OTU domain, ubiquitin aldehyde binding 1
IDBP-532205
OTU domain, ubiquitin aldehyde binding 1
IDBP-536949
OTU domain, ubiquitin aldehyde binding 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19996094
[Homo sapiens] OTUB1 and OTUB2 negatively regulate virus-triggered type I interferon (IFN) induction and cellular antiviral response by deubiquitinating TRAF3 and -6.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167770:
The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:7198202-7206316
Strand Reverse strand
Band A
Transcripts
ENSMUST00000025679 ENSMUSP00000025679
ENSMUST00000123594 ENSMUSP00000115195
ENSMUST00000127241
ENSMUST00000142085 ENSMUSP00000122945
ENSMUST00000123743
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 61 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008242 omega peptidase activity
GO:0019784 NEDD8-specific protease activity
GO:0031625 ubiquitin protein ligase binding
GO:0043130 ubiquitin binding
Biological Process
GO:0002376 immune system process
GO:0006281 DNA repair
GO:0006508 proteolysis
GO:0006974 cellular response to DNA damage stimulus
GO:0019538 protein metabolic process
GO:0071108 protein K48-linked deubiquitination
GO:1901315 negative regulation of histone H2A K63-linked ubiquitination
GO:2000780 negative regulation of double-strand break repair
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167770
View Gene Order
ENSBTAG00000003967
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.203921 Mm.440389
RefSeq NM_134150
OMIM
CCDS CCDS29520
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca