Version 5.4
Homo sapiens Gene: PPARGC1B
Summary
InnateDB Gene IDBG-53101.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPARGC1B
Gene Name peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000155846
Encoded Proteins
IDBP-53103
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
IDBP-53105
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
IDBP-241814
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
IDBP-295296
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
IDBP-379868
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21966468
PPARGC1B is activated in Staphylococcus aureus-mediated sepsis via the TLR2-signalling pathway. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 21966468
[Mus musculus] Ppargc1b is activated in Staphylococcus aureus-mediated sepsis via the Tlr2-signalling pathway.
Entrez Gene
Summary The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:149730298-149855022
Strand Forward strand
Band q32
Transcripts
ENST00000309241 ENSP00000312649
ENST00000360453 ENSP00000353638
ENST00000394320 ENSP00000377855
ENST00000403750 ENSP00000384403
ENST00000434684 ENSP00000409364
ENST00000461780
ENST00000492495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 5 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030331 estrogen receptor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0030546 receptor activator activity
GO:0050682 AF-2 domain binding
Biological Process
GO:0001503 ossification
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006390 transcription from mitochondrial promoter
GO:0007015 actin filament organization
GO:0010694 positive regulation of alkaline phosphatase activity
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0034614 cellular response to reactive oxygen species
GO:0042327 positive regulation of phosphorylation
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045672 positive regulation of osteoclast differentiation
GO:0045780 positive regulation of bone resorption
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051384 response to glucocorticoid
GO:0051591 response to cAMP
GO:0060346 bone trabecula formation
GO:2000273 positive regulation of receptor activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0016592 mediator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033871
View Gene Order
ENSBTAG00000012943
Not yet available
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q86YN6
TrEMBL
UniProt Splice Variant
Entrez Gene 133522
UniGene Hs.483816
RefSeq NM_001172699 NM_001172698 NM_133263 XM_005268372
HUGO HGNC:30022
OMIM 608886
CCDS CCDS54934 CCDS4298 CCDS54933
HPRD 10594
IMGT
EMBL AC008545 AC022100 AF468496 AF468497 AK095391 AK123614 AY188947 AY188948 AY188949 AY188950 BC132971 BC132973 CH471062
GenPept AAI32972 AAI32974 AAL78633 AAL78634 AAO40022 AAO40023 AAO40024 AAO40025 BAC04541 BAG53922 EAW61759
RNA Seq Atlas 133522

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca