Version 5.4
Homo sapiens Gene: FERMT3
Summary
InnateDB Gene IDBG-53150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FERMT3
Gene Name fermitin family member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149781
Encoded Proteins
IDBP-53152
fermitin family member 3
IDBP-53154
fermitin family member 3
IDBP-594900
fermitin family member 3
IDBP-584455
fermitin family member 3
IDBP-585150
fermitin family member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:64206678-64223886
Strand Forward strand
Band q13.1
Transcripts
ENST00000279227 ENSP00000279227
ENST00000345728 ENSP00000339950
ENST00000544997 ENSP00000445778
ENST00000541252 ENSP00000438885
ENST00000541326
ENST00000546255
ENST00000540957
ENST00000545896 ENSP00000440209
ENST00000540554
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
Biological Process
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0033622 integrin activation
GO:0033632 regulation of cell-cell adhesion mediated by integrin
GO:0034446 substrate adhesion-dependent cell spreading
GO:0070527 platelet aggregation
Cellular Component
GO:0002102 podosome
GO:0016020 membrane
GO:0030054 cell junction
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000024965
View Gene Order
Cross-References
SwissProt Q86UX7
TrEMBL F5H1C6 F5H3I6
UniProt Splice Variant
Entrez Gene 83706
UniGene Hs.180535
RefSeq NM_178443 NM_031471 XM_006718703 XM_006718704 XM_006718705
HUGO HGNC:23151
OMIM 607901
CCDS CCDS8060 CCDS8059
HPRD 07440
IMGT
EMBL AK093719 AP005668 AY093951 AY093952 BC004347 BC013366 BC015584
GenPept AAH04347 AAH13366 AAH15584 AAM19736 AAM19737 BAC04220
RNA Seq Atlas 83706

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca