InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHRM5

Summary

InnateDB Gene

IDBG-5327.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRM5

Gene Name

cholinergic receptor, muscarinic 5

Synonyms

HM5

Species

Homo sapiens

Ensembl Gene

ENSG00000184984

Encoded Proteins

IDBP-125192

cholinergic receptor, muscarinic 5

IDBP-586747

cholinergic receptor, muscarinic 5

IDBP-603331

cholinergic receptor, muscarinic 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:33968720-34067457

Strand

Forward strand

Band

q14

Transcripts

ENST00000383263	ENSP00000372750
ENST00000560035	ENSP00000452742
ENST00000557872	ENSP00000453745

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0016907	G-protein coupled acetylcholine receptor activity

Biological Process

GO:0001696	gastric acid secretion
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0015872	dopamine transport
GO:0019226	transmission of nerve impulse
GO:0060304	regulation of phosphatidylinositol dephosphorylation

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000074939

View Gene Order

ENSBTAG00000037985

Not yet available

Pathways

NETPATH

REACTOME

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_16943

Muscarinic acetylcholine receptors pathway

REACT_16983

Amine ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04020

Calcium signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

H0YKC0

UniProt Splice Variant

Entrez Gene

1133

UniGene

Hs.584747

RefSeq

NM_012125

HUGO

HGNC:1954

OMIM

118496

CCDS

CCDS10031

HPRD

00331

IMGT

EMBL

AC009268 AC069045

GenPept

RNA Seq Atlas

1133