InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHRM5

Summary

InnateDB Protein

IDBP-125192.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRM5

Protein Name

cholinergic receptor, muscarinic 5

Synonyms

HM5;

Species

Homo sapiens

Ensembl Protein

ENSP00000372750

InnateDB Gene

IDBG-5327 (CHRM5)

Protein Structure

UniProt Annotation

Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0016907	G-protein coupled acetylcholine receptor activity

Biological Process

GO:0001696	gastric acid secretion
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0015872	dopamine transport
GO:0019226	transmission of nerve impulse
GO:0060304	regulation of phosphatidylinositol dephosphorylation

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000502 Muscarinic acetylcholine receptor M5
IPR000995 Muscarinic acetylcholine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00542
PR00243

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08912