InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: G6PC3

Summary

InnateDB Gene

IDBG-53289.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

G6PC3

Gene Name

glucose 6 phosphatase, catalytic, 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000141349

Encoded Proteins

IDBP-53291

glucose 6 phosphatase, catalytic, 3

IDBP-764475

IDBP-763176

IDBP-761060

IDBP-764466

IDBP-758051

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the catalytic subunit of glucose-6-phosphatase (G6Pase). G6Pase is located in the endoplasmic reticulum (ER) and catalyzes the hydrolysis of glucose-6-phosphate to glucose and phosphate in the last step of the gluconeogenic and glycogenolytic pathways. Mutations in this gene result in autosomal recessive severe congenital neutropenia. Multiple transcript variants have been found for this gene, only one of which is expected to express a protein.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:44070735-44076344

Strand

Forward strand

Band

q21.31

Transcripts

ENST00000269097	ENSP00000269097
ENST00000590639
ENST00000585962
ENST00000591696	ENSP00000468677
ENST00000588558	ENSP00000467624
ENST00000593115	ENSP00000466821
ENST00000590253	ENSP00000465111
ENST00000585361	ENSP00000466983

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004346	glucose-6-phosphatase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006094	gluconeogenesis
GO:0006796	phosphate-containing compound metabolic process
GO:0008152	metabolic process
GO:0008645	hexose transport
GO:0015758	glucose transport
GO:0015760	glucose-6-phosphate transport
GO:0016311	dephosphorylation
GO:0044281	small molecule metabolic process
GO:0051156	glucose 6-phosphate metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000034793

View Gene Order

ENSBTAG00000016253

Not yet available

Pathways

NETPATH

REACTOME

REACT_212

Glucose transport pathway

REACT_9441

Hexose transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_200783

Myoclonic epilepsy of Lafora pathway

REACT_474

Metabolism of carbohydrates pathway

REACT_111217

Metabolism pathway

REACT_19118

SLC-mediated transmembrane transport pathway

REACT_116125

Disease pathway

REACT_200833

Glycogen storage diseases pathway

KEGG

hsa00052

Galactose metabolism pathway

hsa00010

Glycolysis / Gluconeogenesis pathway

hsa04910

Insulin signaling pathway pathway

hsa00500

Starch and sucrose metabolism pathway

hsa04920

Adipocytokine signaling pathway pathway

hsa04973

Carbohydrate digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

K7EQ13

UniProt Splice Variant

Entrez Gene

92579

UniGene

Hs.294005

RefSeq

NM_138387

HUGO

HGNC:24861

OMIM

611045

CCDS

CCDS11476

HPRD

13556

IMGT

EMBL

AC023855

GenPept

RNA Seq Atlas

92579