Version 5.4
Homo sapiens Gene: FKBP2
Summary
InnateDB Gene IDBG-53311.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FKBP2
Gene Name FK506 binding protein 2, 13kDa
Synonyms FKBP-13; PPIase
Species Homo sapiens
Ensembl Gene ENSG00000173486
Encoded Proteins
IDBP-53313
FK506 binding protein 2, 13kDa
IDBP-241385
FK506 binding protein 2, 13kDa
IDBP-377109
FK506 binding protein 2, 13kDa
IDBP-591922
FK506 binding protein 2, 13kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:64241003-64244132
Strand Forward strand
Band q13.1
Transcripts
ENST00000309366 ENSP00000310935
ENST00000394540 ENSP00000378046
ENST00000449942 ENSP00000398147
ENST00000536642
ENST00000541388
ENST00000535135 ENSP00000438749
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 17 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0005528 FK506 binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000056629
View Gene Order
ENSBTAG00000013606
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001135208 NM_004470 NM_057092
HUGO
OMIM
CCDS CCDS8063
HPRD 01742
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca