InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CAMK2A

Summary

InnateDB Gene

IDBG-53452.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAMK2A

Gene Name

calcium/calmodulin-dependent protein kinase II alpha

Synonyms

CAMKA

Species

Homo sapiens

Ensembl Gene

ENSG00000070808

Encoded Proteins

IDBP-53456

calcium/calmodulin-dependent protein kinase II alpha

IDBP-233134

calcium/calmodulin-dependent protein kinase II alpha

IDBP-477409

calcium/calmodulin-dependent protein kinase II alpha

IDBP-474697

calcium/calmodulin-dependent protein kinase II alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18818394

CAMK2A promotes TLR-triggered pro-inflammatory cytokine and type-I-IFN production by directly binding and activating MAP3K7 and IRF3 in macrophages. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 18818394

[Mus musculus] Camk2a promotes Tlr-triggered pro-inflammatory cytokine and type-I-IFN production by directly binding and activating Map3k7 and Irf3 in mouse macrophages.

Entrez Gene

Summary

The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:150219491-150290291

Strand

Reverse strand

Band

q32

Transcripts

ENST00000351010
ENST00000348628	ENSP00000261793
ENST00000398376	ENSP00000381412
ENST00000508662
ENST00000515758	ENSP00000427580
ENST00000510347	ENSP00000426607
ENST00000507995

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	50 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0035254	glutamate receptor binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0006816	calcium ion transport
GO:0007268	synaptic transmission
GO:0019221	cytokine-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation
GO:0046928	regulation of neurotransmitter secretion
GO:0048168	regulation of neuronal synaptic plasticity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060333	interferon-gamma-mediated signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0030666	endocytic vesicle membrane
GO:0042734	presynaptic membrane