Version 5.4
Mus musculus Gene: Camk2a
Summary
InnateDB Gene IDBG-150657.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Camk2a
Gene Name calcium/calmodulin-dependent protein kinase II alpha
Synonyms CaMKII; mKIAA0968; R74975
Species Mus musculus
Ensembl Gene ENSMUSG00000024617
Encoded Proteins
IDBP-150659
calcium/calmodulin-dependent protein kinase II alpha
IDBP-150661
calcium/calmodulin-dependent protein kinase II alpha
IDBP-150665
calcium/calmodulin-dependent protein kinase II alpha
IDBP-249948
calcium/calmodulin-dependent protein kinase II alpha
IDBP-249950
calcium/calmodulin-dependent protein kinase II alpha
IDBP-541251
calcium/calmodulin-dependent protein kinase II alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18818394
Camk2a promotes Tlr-triggered pro-inflammatory cytokine and type-I-IFN production by directly binding and activating Map3k7 and Irf3 in mouse macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 18818394
[Homo sapiens] CAMK2A promotes TLR-triggered pro-inflammatory cytokine and type-I-IFN production by directly binding and activating MAP3K7 and IRF3 in macrophages. (Demonstrated in murine model)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070808:
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:60925618-60988152
Strand Forward strand
Band E1
Transcripts
ENSMUST00000102888 ENSMUSP00000099952
ENSMUST00000025519 ENSMUSP00000025519
ENSMUST00000039904 ENSMUSP00000048325
ENSMUST00000115297 ENSMUSP00000110952
ENSMUST00000115295 ENSMUSP00000110950
ENSMUST00000134496
ENSMUST00000137805 ENSMUSP00000123480
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0035254 glutamate receptor binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0006816 calcium ion transport
GO:0045087 innate immune response (InnateDB)
GO:0046777 protein autophosphorylation
GO:0046928 regulation of neurotransmitter secretion
GO:0048168 regulation of neuronal synaptic plasticity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005954 calcium- and calmodulin-dependent protein kinase complex
GO:0030054 cell junction
GO:0042734 presynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000070808
View Gene Order
ENSBTAG00000020087
Not yet available
Pathways
NETPATH
REACTOME
REACT_214014
Signaling by Wnt pathway
REACT_188957
Cellular responses to stress pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_198244
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_198246
CREB phosphorylation through the activation of Ras pathway
REACT_198248
CREB phosphorylation through the activation of CaMKII pathway
REACT_230745
Immune System pathway
REACT_218233
Post NMDA receptor activation events pathway
REACT_213550
HSF1-dependent transactivation pathway
REACT_224790
Cellular response to heat stress pathway
REACT_198660
Interferon gamma signaling pathway
REACT_198666
Interferon Signaling pathway
REACT_221970
Ca2+ pathway pathway
REACT_259290
Neuronal System pathway
REACT_258217
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_188257
Signal Transduction pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_214376
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
KEGG
mmu04740
Olfactory transduction pathway
mmu04012
ErbB signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu04916
Melanogenesis pathway
mmu04310
Wnt signaling pathway pathway
mmu04912
GnRH signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu05214
Glioma pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04114
Oocyte meiosis pathway
mmu04971
Gastric acid secretion pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_25078
Interferon gamma signaling pathway
REACT_20546
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_20642
CREB phosphorylation through the activation of CaMKII pathway
REACT_20594
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_18307
Trafficking of AMPA receptors pathway
REACT_120956
Cellular responses to stress pathway
REACT_172761
Ca2+ pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_13685
Neuronal System pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_111102
Signal Transduction pathway
REACT_25229
Interferon Signaling pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_6900
Immune System pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_200775
HSF1-dependent transactivation pathway
REACT_200819
Cellular response to heat stress pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_18347
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04310
Wnt signaling pathway pathway
hsa04740
Olfactory transduction pathway
hsa04012
ErbB signaling pathway pathway
hsa04720
Long-term potentiation pathway
hsa05214
Glioma pathway
hsa04020
Calcium signaling pathway pathway
hsa04916
Melanogenesis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04114
Oocyte meiosis pathway
hsa04971
Gastric acid secretion pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
netrin_pathway
Netrin-mediated signaling events
fgf_pathway
FGF signaling pathway
tgfbrpathway
TGF-beta receptor signaling
wnt_noncanonical_pathway
Noncanonical Wnt signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.131530 Mm.402799 Mm.418438 Mm.463745
RefSeq NM_001286809 NM_009792 NM_177407 XM_006525542
OMIM
CCDS CCDS29276 CCDS29277 CCDS70898
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca