Version 5.4
Homo sapiens Gene: IFNA2
Summary
InnateDB Gene IDBG-54199.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFNA2
Gene Name interferon, alpha 2
Synonyms IFN-alphaA; IFNA; IFNA2B; INFA2
Species Homo sapiens
Ensembl Gene ENSG00000188379
Encoded Proteins
IDBP-54201
interferon, alpha 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18729739
IFNA2 controls chemotaxis by regulating the CXC receptor ligand interaction between CXCL10 and CXCR3A.
PMID 18027911
IFNA2 interacts differentially with IFNAR2, and influences IFNA1 interaction with IFNAR2.
PMID 18606657
IFNA2 induces the transcription of HIF1A in human endothelial cells though a JAK-ISGF3 pathway under normoxic conditions, and this response contributes to the anti-proliferative activity of this cytokine.
Entrez Gene
Summary This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:21384254-21385388
Strand Reverse strand
Band p21.3
Transcripts
ENST00000380206 ENSP00000369554
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 5 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005132 type I interferon receptor binding
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007596 blood coagulation
GO:0010629 negative regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045087 innate immune response (InnateDB)
GO:0045581 negative regulation of T cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046597 negative regulation of viral entry into host cell
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:2000552 negative regulation of T-helper 2 cell cytokine production
GO:2000663 negative regulation of interleukin-5 secretion
GO:2000666 negative regulation of interleukin-13 secretion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_24938
TRAF6 mediated IRF7 activation pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_25216
Regulation of IFNA signaling pathway
REACT_25162
Interferon alpha/beta signaling pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
hsa04140
Regulation of autophagy pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05320
Autoimmune thyroid disease pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
hsa04623
Cytosolic DNA-sensing pathway pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
INOH website
IFN alpha signaling pathway
PID NCI
Cross-References
SwissProt P01563
TrEMBL Q16054
UniProt Splice Variant
Entrez Gene 3440
UniGene Hs.211575
RefSeq NM_000605
HUGO HGNC:5423
OMIM 147562
CCDS CCDS6506
HPRD
IMGT
EMBL BC074936 BC074937 BC104163 BC104164 CH471071 CR541921 J00207 JN591568 JN591569 JN591570 JN848522 M29883 M54886 S64991 V00544 V00548 V00549 Y11834
GenPept AAA52715 AAA59181 AAB59402 AAD13961 AAH74936 AAH74937 AAI04164 AAI04165 AET86951 AEX60802 AEX60803 AEX60804 CAA23805 CAA23809 CAA23810 CAA72532 CAG46719 EAW58611
RNA Seq Atlas 3440

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca