InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFNA2

Summary

InnateDB Protein

IDBP-54201.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFNA2

Protein Name

interferon, alpha 2

Synonyms

IFN-alphaA; IFNA; IFNA2B; INFA2;

Species

Homo sapiens

Ensembl Protein

ENSP00000369554

InnateDB Gene

IDBG-54199 (IFNA2)

Protein Structure

UniProt Annotation

Function

Produced by macrophages, IFN-alpha have antiviral activities.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005132	type I interferon receptor binding
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006952	defense response
GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007596	blood coagulation
GO:0010629	negative regulation of gene expression
GO:0019221	cytokine-mediated signaling pathway
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045087	innate immune response (InnateDB)
GO:0045581	negative regulation of T cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046597	negative regulation of viral entry into host cell
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway
GO:2000552	negative regulation of T-helper 2 cell cytokine production
GO:2000663	negative regulation of interleukin-5 secretion
GO:2000666	negative regulation of interleukin-13 secretion