Version 5.4
Homo sapiens Gene: DBF4B
Summary
InnateDB Gene IDBG-54210.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DBF4B
Gene Name DBF4 homolog B (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000161692
Encoded Proteins
IDBP-54212
DBF4 homolog B (S. cerevisiae)
IDBP-243397
DBF4 homolog B (S. cerevisiae)
IDBP-587905
DBF4 homolog B (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:44708608-44752264
Strand Forward strand
Band q21.31
Transcripts
ENST00000315005 ENSP00000323663
ENST00000393547 ENSP00000377178
ENST00000528766
ENST00000528353
ENST00000526924 ENSP00000431158
ENST00000526915
ENST00000525140
ENST00000531699
ENST00000532789
ENST00000527862
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0030295 protein kinase activator activity
Biological Process
GO:0007049 cell cycle
GO:0008284 positive regulation of cell proliferation
GO:0010571 positive regulation of nuclear cell cycle DNA replication
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0045860 positive regulation of protein kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016235 aggresome
GO:0043231 intracellular membrane-bounded organelle
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q8NFT6
TrEMBL B3KWT3 B4E099
UniProt Splice Variant
Entrez Gene 80174
UniGene Hs.369998
RefSeq NM_025104 NM_145663 XM_006722102 XM_006722105
HUGO HGNC:17883
OMIM 611661
CCDS CCDS11485 CCDS45706
HPRD
IMGT
EMBL AC005180 AC091152 AF448801 AF465820 AK023149 AK125771 AK303282 BC016158 CH471178
GenPept AAH16158 AAL75985 AAM73808 BAB14431 BAG54245 BAG64361 EAW51581 EAW51582 EAW51584 EAW51586 EAW51587
RNA Seq Atlas 80174

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca