InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DBF4B

Summary

InnateDB Protein

IDBP-243397.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DBF4B

Protein Name

DBF4 homolog B (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000377178

InnateDB Gene

IDBG-54210 (DBF4B)

Protein Structure

UniProt Annotation

Function

Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269PubMed:12065429, ECO:0000269PubMed:15668232, ECO:0000269PubMed:17062569}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12065429, ECO:0000269PubMed:15668232}. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in testis. {ECO:0000269PubMed:12065429}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0008270	zinc ion binding
GO:0019901	protein kinase binding
GO:0030295	protein kinase activator activity

Biological Process

GO:0007049	cell cycle
GO:0008284	positive regulation of cell proliferation
GO:0010571	positive regulation of nuclear cell cycle DNA replication
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0045860	positive regulation of protein kinase activity