Version 5.4
Homo sapiens Gene: HCFC2
Summary
InnateDB Gene IDBG-54267.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HCFC2
Gene Name host cell factor C2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111727
Encoded Proteins
IDBP-54269
host cell factor C2
IDBP-600643
host cell factor C2
IDBP-587353
host cell factor C2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:104064457-104106524
Strand Forward strand
Band q23.3
Transcripts
ENST00000229330 ENSP00000229330
ENST00000544223 ENSP00000442942
ENST00000550444 ENSP00000447952
ENST00000547194
ENST00000550335
ENST00000552343
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 13 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0016032 viral process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020246
View Gene Order
ENSBTAG00000020933
Not yet available
Cross-References
SwissProt
TrEMBL F8VU09
UniProt Splice Variant
Entrez Gene 29915
UniGene Hs.506558 Hs.707252
RefSeq NM_013320
HUGO HGNC:24972
OMIM 607926
CCDS CCDS9097
HPRD 06393
IMGT
EMBL AC078819 AC084359 AC089983
GenPept
RNA Seq Atlas 29915

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca