Version 5.4
Homo sapiens Protein: HCFC2
Summary
InnateDB Protein IDBP-54269.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HCFC2
Protein Name host cell factor C2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000229330
InnateDB Gene IDBG-54267 (HCFC2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm {ECO:0000269PubMed:10196288}. Nucleus {ECO:0000269PubMed:10196288}.
Disease Associations
Tissue Specificity Highly expressed in testis. Detected at lower levels in spleen, thymus, prostate, ovary, small intestine and colon. {ECO:0000269PubMed:10196288}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 13 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0016032 viral process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR003961 Fibronectin, type III
IPR006652 Kelch repeat type 1
PFAM PF00041
PF01108
PF01344
PRINTS
PIRSF
SMART SM00060
SM00612
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y5Z7
PhosphoSite PhosphoSite-Q9Y5Z7
TrEMBL F8VU09
UniProt Splice Variant
Entrez Gene 29915
UniGene Hs.707252
RefSeq NP_037452
HUGO HGNC:24972
OMIM 607926
CCDS CCDS9097
HPRD 06393
IMGT
EMBL AC078819 AC084359 AC089983 AF117210 AK313466 BC033799 CH471054
GenPept AAD27814 AAH33799 BAG36252 EAW97737

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca