Version 5.4
| Homo sapiens Gene: CEACAM1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-54381.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | CEACAM1 | ||||||||||||||||||
| Gene Name | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | ||||||||||||||||||
| Synonyms | BGP; BGP1; BGPI | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000079385 | ||||||||||||||||||
| Encoded Proteins |
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
CEACAM1 inhibits TLR2 induced pro-inflammatory immune responses by inducing PTPN6-(SHP-1)-mediated inhibition of the PI3K-NF-kappaB signal transduction pathway in pulmonary epithelial cells.
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| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 19:42507304-42561234 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q13.2 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH |
EGFR1 pathway
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| REACTOME |
Cell surface interactions at the vascular wall pathway
Fibronectin matrix formation pathway
Extracellular matrix organization pathway
Hemostasis pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.512682 Hs.604089 | ||||||||||||||||||
| RefSeq | NM_001024912 NM_001184813 NM_001184815 NM_001184816 NM_001205344 NM_001712 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS12609 CCDS46089 CCDS54272 CCDS54273 CCDS54274 | ||||||||||||||||||
| HPRD | 00191 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||