InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MTAP

Summary

InnateDB Gene

IDBG-54400.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTAP

Gene Name

methylthioadenosine phosphorylase

Synonyms

BDMF; c86fus; DMSFH; DMSMFH; HEL-249; LGMBF; MSAP

Species

Homo sapiens

Ensembl Gene

ENSG00000099810

Encoded Proteins

IDBP-54406

methylthioadenosine phosphorylase

IDBP-365234

methylthioadenosine phosphorylase

IDBP-717291

IDBP-716898

IDBP-717384

IDBP-717183

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:21802543-21937651

Strand

Forward strand

Band

p21.3

Transcripts

ENST00000380172	ENSP00000369519
ENST00000419385	ENSP00000393507
ENST00000427788
ENST00000460874	ENSP00000461932
ENST00000484957
ENST00000580900	ENSP00000463424
ENST00000580675
ENST00000580718	ENSP00000464616
ENST00000579422
ENST00000577563	ENSP00000462082
ENST00000581962
ENST00000584988
ENST00000616982

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	22 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004645	phosphorylase activity
GO:0004731	purine-nucleoside phosphorylase activity
GO:0017061	S-methyl-5-thioadenosine phosphorylase activity

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0006139	nucleobase-containing compound metabolic process
GO:0006166	purine ribonucleoside salvage
GO:0006595	polyamine metabolic process
GO:0009116	nucleoside metabolic process
GO:0019509	L-methionine biosynthetic process from methylthioadenosine
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000062937

View Gene Order

ENSBTAG00000025929

Not yet available

Pathways

NETPATH

REACTOME

REACT_75881

Methionine salvage pathway pathway

REACT_14820

Metabolism of polyamines pathway

REACT_115639

Sulfur amino acid metabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00270

Cysteine and methionine metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

Q13126

TrEMBL

B4DUC8 F8WES2 J3KRN1 J3QSB7

UniProt Splice Variant

Entrez Gene

4507

UniGene

Hs.193268

RefSeq

NM_002451

HUGO

HGNC:7413

OMIM

156540

CCDS

CCDS6509

HPRD

IMGT

EMBL

AK300592 AL359922 AL449423 AY712791 BC026106 CH471071 HE654772 HE654773 HE654774 HE654775 HE654776 HE654777 L40432 L42627 L42628 L42629 L42630 L42631 L42632 L42633 L42634 U22233

GenPept

AAA81646 AAG38871 AAH26106 AAR24607 AAU04442 BAG62290 CAI16481 CCF77345 CCF77346 CCF77347 CCF77348 CCF77349 CCF77350 EAW58606

RNA Seq Atlas

4507