Version 5.4
Bos taurus Gene: MTAP
Summary
InnateDB Gene IDBG-630044.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTAP
Gene Name S-methyl-5'-thioadenosine phosphorylase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000025929
Encoded Proteins
IDBP-681536
methylthioadenosine phosphorylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099810:
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:22223658-22254686
Strand Reverse strand
Band
Transcripts
ENSBTAT00000048509 ENSBTAP00000045533
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004645 phosphorylase activity
GO:0016763 transferase activity, transferring pentosyl groups
GO:0017061 S-methyl-5-thioadenosine phosphorylase activity
Biological Process
GO:0009116 nucleoside metabolic process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000099810
View Gene Order
ENSMUSG00000062937
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75881
Methionine salvage pathway pathway
REACT_14820
Metabolism of polyamines pathway
REACT_115639
Sulfur amino acid metabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_202492
Sulfur amino acid metabolism pathway
REACT_199099
Methionine salvage pathway pathway
REACT_253147
Metabolism of polyamines pathway
KEGG
hsa00270
Cysteine and methionine metabolism pathway
mmu00270
Cysteine and methionine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq XM_001251562 XM_002689506
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca