Version 5.4
Homo sapiens Gene: DYX1C1
Summary
InnateDB Gene IDBG-544502.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DYX1C1
Gene Name dyslexia susceptibility 1 candidate 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000256061
Encoded Proteins
IDBP-13065
DYX1C1-CCPG1 readthrough (non-protein coding)
IDBP-13067
DYX1C1-CCPG1 readthrough (non-protein coding)
IDBP-373282
DYX1C1-CCPG1 readthrough (non-protein coding)
IDBP-373291
DYX1C1-CCPG1 readthrough (non-protein coding)
IDBP-483674
DYX1C1-CCPG1 readthrough (non-protein coding)
IDBP-484892
DYX1C1-CCPG1 readthrough (non-protein coding)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:55410525-55508234
Strand Reverse strand
Band q21.3
Transcripts
ENST00000321149 ENSP00000323275
ENST00000348518 ENSP00000299561
ENST00000448430 ENSP00000403412
ENST00000457155 ENSP00000402640
ENST00000524160 ENSP00000428097
ENST00000522437 ENSP00000429219
ENST00000519017
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030331 estrogen receptor binding
Biological Process
GO:0001764 neuron migration
GO:0003341 cilium movement
GO:0007368 determination of left/right symmetry
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0036158 outer dynein arm assembly
GO:0036159 inner dynein arm assembly
GO:0061136 regulation of proteasomal protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000092192
View Gene Order
ENSBTAG00000031388
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.126403
RefSeq NM_001033559 NM_001033560 NM_130810
HUGO
OMIM
CCDS CCDS10154 CCDS32243 CCDS32244
HPRD 10568
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca