Version 5.4
Mus musculus Gene: Dyx1c1
Summary
InnateDB Gene IDBG-606025.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dyx1c1
Gene Name dyslexia susceptibility 1 candidate 1 homolog (human)
Synonyms 1700010I24Rik; b2b811Clo; EKN1
Species Mus musculus
Ensembl Gene ENSMUSG00000092192
Encoded Proteins
IDBP-183976
dyslexia susceptibility 1 candidate gene 1 protein homolog isoform 2
IDBP-183978
dyslexia susceptibility 1 candidate gene 1 protein homolog isoform 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000256061:
This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:72958785-72973064
Strand Forward strand
Band D
Transcripts
ENSMUST00000098567 ENSMUSP00000096166
ENSMUST00000034734 ENSMUSP00000034734
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030331 estrogen receptor binding
Biological Process
GO:0001764 neuron migration
GO:0003341 cilium movement
GO:0007368 determination of left/right symmetry
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0036158 outer dynein arm assembly
GO:0036159 inner dynein arm assembly
GO:0061136 regulation of proteasomal protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000256061
View Gene Order
ENSBTAG00000031388
Not yet available
Cross-References
SwissProt Q8R368
TrEMBL E9Q973 Q8C5Z6 Q9CVZ5
UniProt Splice Variant
Entrez Gene 67685
UniGene Mm.31817 Mm.490694
RefSeq NM_001163725 NM_026314 XM_006511381
OMIM
CCDS CCDS23333 CCDS52854
HPRD
IMGT
MGI ID MGI:1914935
MGI Symbol Dyx1c1
EMBL AC158997 AK005832 AK015345 AK076862 AK161368 BC026462 CH466522
GenPept AAH26462 BAB24264 BAB29805 BAC36509 BAE36351 EDL26272
RNA Seq Atlas 67685

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca