Version 5.4
Homo sapiens Gene: FPGT
Summary
InnateDB Gene IDBG-545534.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FPGT
Gene Name fucose-1-phosphate guanylyltransferase
Synonyms GFPP
Species Homo sapiens
Ensembl Gene ENSG00000254685
Encoded Proteins
IDBP-99718
fucose-1-phosphate guanylyltransferase
IDBP-99722
fucose-1-phosphate guanylyltransferase
IDBP-603276
fucose-1-phosphate guanylyltransferase
IDBP-602699
fucose-1-phosphate guanylyltransferase
IDBP-603274
fucose-1-phosphate guanylyltransferase
IDBP-602052
fucose-1-phosphate guanylyltransferase
IDBP-584454
fucose-1-phosphate guanylyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:74198212-74234086
Strand Forward strand
Band p31.1
Transcripts
ENST00000370898 ENSP00000359935
ENST00000370894 ENSP00000359931
ENST00000482102 ENSP00000433044
ENST00000467578 ENSP00000434934
ENST00000472069 ENSP00000433499
ENST00000524915
ENST00000529485 ENSP00000431733
ENST00000534056 ENSP00000432819
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005525 GTP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0047341 fucose-1-phosphate guanylyltransferase activity
Biological Process
GO:0006004 fucose metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053870
View Gene Order
ENSBTAG00000038480
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
hsa00051
Fructose and mannose metabolism pathway
INOH
INOH website
Fructose Mannose metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.480085
RefSeq NM_001199328 NM_001199329 NM_003838
HUGO
OMIM
CCDS CCDS663
HPRD 06790
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca