Version 5.4
Homo sapiens Gene: ALDH1L2
Summary
InnateDB Gene IDBG-54556.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALDH1L2
Gene Name aldehyde dehydrogenase 1 family, member L2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136010
Encoded Proteins
IDBP-54558
aldehyde dehydrogenase 1 family, member L2
IDBP-586214
aldehyde dehydrogenase 1 family, member L2
IDBP-584765
aldehyde dehydrogenase 1 family, member L2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:105019784-105084577
Strand Reverse strand
Band q23.3
Transcripts
ENST00000258494 ENSP00000258494
ENST00000549335
ENST00000552270 ENSP00000447538
ENST00000548418 ENSP00000447464
ENST00000552427
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008168 methyltransferase activity
GO:0016155 formyltetrahydrofolate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016742 hydroxymethyl-, formyl- and related transferase activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0009258 10-formyltetrahydrofolate catabolic process
GO:0032259 methylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020256
View Gene Order
ENSBTAG00000006326
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00670
One carbon pool by folate pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.42572 Hs.605925
RefSeq NM_001034173
HUGO
OMIM
CCDS CCDS31891
HPRD 18742
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca