Version 5.4
Homo sapiens Gene: TRIM34
Summary
InnateDB Gene IDBG-547400.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM34
Gene Name tripartite motif containing 34
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000258659
Encoded Proteins
IDBP-364184
tripartite motif containing 34
IDBP-475656
tripartite motif containing 34
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:5619764-5644398
Strand Forward strand
Band p15.4
Transcripts
ENST00000429814 ENSP00000402595
ENST00000514226 ENSP00000422947
ENST00000491385
ENST00000495668
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070206 protein trimerization
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9BYJ4
TrEMBL
UniProt Splice Variant
Entrez Gene 53840
UniGene Hs.694490
RefSeq NM_001003827 NM_021616
HUGO HGNC:10063
OMIM 605684
CCDS CCDS31391
HPRD
IMGT
EMBL AB039902 AB039903 AB039904 AF220143 AF220144 AK027876 AL583914 CH471064
GenPept AAG53516 AAG53517 BAB17049 BAB17050 BAB17051 BAB55424 CAC29498 EAW68778 EAW68780
RNA Seq Atlas 53840

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca