Version 5.4
Homo sapiens Gene: NOX5
Summary
InnateDB Gene IDBG-547502.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOX5
Gene Name NADPH oxidase, EF-hand calcium binding domain 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000255346
Encoded Proteins
IDBP-585074
NADPH oxidase 5 isoform 3
IDBP-19234
NADPH oxidase, EF-hand calcium binding domain 5
IDBP-376320
NADPH oxidase 5 isoform 3
IDBP-376324
NADPH oxidase 5 isoform 3
IDBP-597762
NADPH oxidase, EF-hand calcium binding domain 5
IDBP-745803
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:68930525-69062743
Strand Forward strand
Band q23
Transcripts
ENST00000260364 ENSP00000454143
ENST00000388866 ENSP00000373518
ENST00000455873 ENSP00000416828
ENST00000448182 ENSP00000410887
ENST00000530406 ENSP00000432440
ENST00000527315
ENST00000525143 ENSP00000455703
ENST00000525163
ENST00000529367
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015252 hydrogen ion channel activity
GO:0016175 superoxide-generating NADPH oxidase activity
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0000910 cytokinesis
GO:0001525 angiogenesis
GO:0001935 endothelial cell proliferation
GO:0006915 apoptotic process
GO:0008283 cell proliferation
GO:0010155 regulation of proton transport
GO:0015992 proton transport
GO:0042554 superoxide anion generation
GO:0043012 regulation of fusion of sperm to egg plasma membrane
GO:0050663 cytokine secretion
GO:0055114 oxidation-reduction process
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 79400
UniGene Hs.133438 Hs.657932
RefSeq NM_001184779 NM_001184780 NM_024505
HUGO HGNC:14874
OMIM 606572
CCDS CCDS32276 CCDS53953 CCDS53954
HPRD 07359
IMGT
EMBL
GenPept
RNA Seq Atlas 79400

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca