InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOX5

Summary

InnateDB Protein

IDBP-376324.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOX5

Protein Name

NADPH oxidase 5 isoform 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000410887

InnateDB Gene

IDBG-547502 (NOX5)

Protein Structure

UniProt Annotation

Function

Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. {ECO:0000269PubMed:11483596, ECO:0000269PubMed:12686516, ECO:0000269PubMed:17275676}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.Isoform v2: Endoplasmic reticulum.Isoform v5: Endoplasmic reticulum.

Disease Associations

Tissue Specificity

Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen and lymph nodes. Isoform v1 is expressed in spleen. Isoform v2 is expressed in testis. Also detected in ovary, placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells. Isoform v1 and isoform v3 are expressed in epithelial colorectal adenocarcinoma cells. Isoform v2 and isoform v4 are expressed in endothelial cells. Isoform v1, isoform v2, isoform v3 and isoform v4 are expressed in pulmonary artery smooth muscle cells. Isoform v2 and isoform v5 are expressed in microvascular endothelial cells (at protein level). {ECO:0000269PubMed:11376945, ECO:0000269PubMed:11483596, ECO:0000269PubMed:12686516, ECO:0000269PubMed:16179589, ECO:0000269PubMed:16339585, ECO:0000269PubMed:17275676}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0015252	hydrogen ion channel activity
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0000910	cytokinesis
GO:0001525	angiogenesis
GO:0001935	endothelial cell proliferation
GO:0006915	apoptotic process
GO:0008283	cell proliferation
GO:0010155	regulation of proton transport
GO:0015992	proton transport
GO:0042554	superoxide anion generation
GO:0043012	regulation of fusion of sperm to egg plasma membrane
GO:0050663	cytokine secretion
GO:0055114	oxidation-reduction process
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002048 EF-hand domain
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF00036
PF13202
PF13405
PF08022
PF08030
PF01794

PRINTS

PIRSF

SMART

SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96PH1