Version 5.4
Homo sapiens Gene: NFU1
Summary
InnateDB Gene IDBG-54874.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFU1
Gene Name NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000169599
Encoded Proteins
IDBP-54876
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
IDBP-241861
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
IDBP-295675
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
IDBP-378273
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
IDBP-378281
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
IDBP-378283
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
IDBP-484016
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
IDBP-479443
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
IDBP-480158
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:69395750-69437628
Strand Reverse strand
Band p13.3
Transcripts
ENST00000303698 ENSP00000306965
ENST00000394305 ENSP00000377842
ENST00000410022 ENSP00000387219
ENST00000450796 ENSP00000415102
ENST00000419370 ENSP00000405495
ENST00000438184 ENSP00000393338
ENST00000471185
ENST00000474230 ENSP00000418882
ENST00000462320 ENSP00000418598
ENST00000484177 ENSP00000417693
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0016226 iron-sulfur cluster assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029993
View Gene Order
ENSBTAG00000000141
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001002755 NM_001002756 NM_015700 XM_006711988
HUGO
OMIM
CCDS CCDS33217 CCDS42694 CCDS46315
HPRD 12163
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca