Version 5.4
Homo sapiens Gene: IFNK
Summary
InnateDB Gene IDBG-55417.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFNK
Gene Name interferon, kappa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147896
Encoded Proteins
IDBP-55419
interferon, kappa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:27524314-27526498
Strand Forward strand
Band p21.2
Transcripts
ENST00000276943 ENSP00000276943
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005132 type I interferon receptor binding
Biological Process
GO:0002250 adaptive immune response
GO:0002286 T cell activation involved in immune response
GO:0002323 natural killer cell activation involved in immune response
GO:0006355 regulation of transcription, DNA-templated
GO:0006952 defense response
GO:0006959 humoral immune response
GO:0008285 negative regulation of cell proliferation
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0030101 natural killer cell activation
GO:0030183 B cell differentiation
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0042100 B cell proliferation
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045343 regulation of MHC class I biosynthetic process
GO:0051607 defense response to virus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000042993
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9P0W0
TrEMBL
UniProt Splice Variant
Entrez Gene 56832
UniGene Hs.591083
RefSeq NM_020124
HUGO HGNC:21714
OMIM 615326
CCDS CCDS6521
HPRD
IMGT
EMBL AF146759 AF315688 AF384048 AL451123 AY358855
GenPept AAF67468 AAK01623 AAK63835 AAQ89214 CAI13042
RNA Seq Atlas 56832

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca