Version 5.4
Homo sapiens Protein: IFNK
Summary
InnateDB Protein IDBP-55419.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFNK
Protein Name interferon, kappa
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000276943
InnateDB Gene IDBG-55417 (IFNK)
Protein Structure
UniProt Annotation
Function May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin. {ECO:0000269PubMed:11514542, ECO:0000269PubMed:12391192}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in keratinocytes, monocytes and in resting dendritic cells. {ECO:0000269PubMed:11514542, ECO:0000269PubMed:12391192}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005132 type I interferon receptor binding
Biological Process
GO:0002250 adaptive immune response
GO:0002286 T cell activation involved in immune response
GO:0002323 natural killer cell activation involved in immune response
GO:0006355 regulation of transcription, DNA-templated
GO:0006952 defense response
GO:0006959 humoral immune response
GO:0008285 negative regulation of cell proliferation
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0030101 natural killer cell activation
GO:0030183 B cell differentiation
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0042100 B cell proliferation
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045343 regulation of MHC class I biosynthetic process
GO:0051607 defense response to virus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR000471 Interferon alpha/beta/delta
IPR009079 Four-helical cytokine-like, core
PFAM PF00143
PRINTS PR00266
PIRSF
SMART SM00076
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P0W0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 56832
UniGene Hs.591083
RefSeq NP_064509
HUGO HGNC:21714
OMIM 615326
CCDS CCDS6521
HPRD 17133
IMGT
EMBL AF146759 AF315688 AF384048 AL451123 AY358855
GenPept AAF67468 AAK01623 AAK63835 AAQ89214 CAI13042

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca