Version 5.4
Homo sapiens Gene: DUSP22
Summary
InnateDB Gene IDBG-55595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP22
Gene Name dual specificity phosphatase 22
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112679
Encoded Proteins
IDBP-55597
dual specificity phosphatase 22
IDBP-360615
dual specificity phosphatase 22
IDBP-812014
dual specificity phosphatase 22
IDBP-812034
dual specificity phosphatase 22
IDBP-812035
dual specificity phosphatase 22
IDBP-812036
dual specificity phosphatase 22
IDBP-812048
dual specificity phosphatase 22
IDBP-812051
dual specificity phosphatase 22
IDBP-812052
dual specificity phosphatase 22
IDBP-812054
dual specificity phosphatase 22
IDBP-812055
dual specificity phosphatase 22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 6:291630-351355
Strand Forward strand
Band p25.3
Transcripts
ENST00000344450 ENSP00000345281
ENST00000419235 ENSP00000397459
ENST00000603296 ENSP00000474082
ENST00000603453 ENSP00000474646
ENST00000605315 ENSP00000474827
ENST00000603881 ENSP00000474450
ENST00000603795 ENSP00000475106
ENST00000605035 ENSP00000475061
ENST00000605863 ENSP00000474000
ENST00000603005
ENST00000603726 ENSP00000474330
ENST00000603290
ENST00000605391
ENST00000604971 ENSP00000474505
ENST00000604914
ENST00000604988
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000188 inactivation of MAPK activity
GO:0006470 protein dephosphorylation
GO:0006915 apoptotic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0008283 cell proliferation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042127 regulation of cell proliferation
GO:0046330 positive regulation of JNK cascade
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000069255
View Gene Order
ENSBTAG00000027375
Not yet available
Cross-References
SwissProt
TrEMBL S4R3K1
UniProt Splice Variant
Entrez Gene 56940
UniGene
RefSeq NM_001286555 NM_020185 XM_005275983
HUGO HGNC:16077
OMIM
CCDS CCDS4468 CCDS69035
HPRD
IMGT
EMBL AL365272
GenPept
RNA Seq Atlas 100653247 56940

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca