Version 5.4
Homo sapiens Gene: CD207
Summary
InnateDB Gene IDBG-55659.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD207
Gene Name CD207 molecule, langerin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116031
Encoded Proteins
IDBP-295615
CD207 molecule, langerin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:70830214-70835822
Strand Reverse strand
Band p13.3
Transcripts
ENST00000410009 ENSP00000386378
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005537 mannose binding
GO:0030246 carbohydrate binding
Biological Process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0051607 defense response to virus
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030139 endocytic vesicle
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031901 early endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034783
View Gene Order
ENSBTAG00000004562
Not yet available
Pathways
NETPATH
REACTOME
REACT_111056
Cross-presentation of soluble exogenous antigens (endosomes) pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9UJ71
TrEMBL
UniProt Splice Variant
Entrez Gene 50489
UniGene Hs.199731
RefSeq NM_015717
HUGO HGNC:17935
OMIM 604862
CCDS CCDS74520
HPRD 07278
IMGT
EMBL AC007395 AJ242859 BC022278
GenPept AAH22278 CAB62403
RNA Seq Atlas 50489

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca