InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WNT3

Summary

InnateDB Gene

IDBG-55691.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT3

Gene Name

wingless-type MMTV integration site family, member 3

Synonyms

INT4

Species

Homo sapiens

Ensembl Gene

ENSG00000108379

Encoded Proteins

IDBP-55693

wingless-type MMTV integration site family, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98%% amino acid identity to mouse Wnt3 protein, and 84%% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:46762506-46833154

Strand

Reverse strand

Band

q21.32

Transcripts

ENST00000225512	ENSP00000225512
ENST00000572508
ENST00000576471
ENST00000573788

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0048018	receptor agonist activity

Biological Process

GO:0000902	cell morphogenesis
GO:0001707	mesoderm formation
GO:0007275	multicellular organismal development
GO:0007276	gamete generation
GO:0007411	axon guidance
GO:0009948	anterior/posterior axis specification
GO:0009950	dorsal/ventral axis specification
GO:0009952	anterior/posterior pattern specification
GO:0010628	positive regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0035115	embryonic forelimb morphogenesis
GO:0035116	embryonic hindlimb morphogenesis
GO:0044338	canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation
GO:0044339	canonical Wnt receptor signaling pathway involved in osteoblast differentiation
GO:0045165	cell fate commitment
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048697	positive regulation of collateral sprouting in absence of injury
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0060064	Spemann organizer formation at the anterior end of the primitive streak
GO:0060070	canonical Wnt signaling pathway
GO:0060173	limb development
GO:0060174	limb bud formation
GO:0060323	head morphogenesis
GO:0061180	mammary gland epithelium development
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0031012	extracellular matrix