InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WNT3

Summary

InnateDB Protein

IDBP-55693.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT3

Protein Name

wingless-type MMTV integration site family, member 3

Synonyms

INT4;

Species

Homo sapiens

Ensembl Protein

ENSP00000225512

InnateDB Gene

IDBG-55691 (WNT3)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tetraamelia, autosomal recessive (ARTTRA) [MIM:273395]: A rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects. {ECO:0000269PubMed:14872406}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0048018	receptor agonist activity

Biological Process

GO:0000902	cell morphogenesis
GO:0001707	mesoderm formation
GO:0007275	multicellular organismal development
GO:0007276	gamete generation
GO:0007411	axon guidance
GO:0009948	anterior/posterior axis specification
GO:0009950	dorsal/ventral axis specification
GO:0009952	anterior/posterior pattern specification
GO:0010628	positive regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0035115	embryonic forelimb morphogenesis
GO:0035116	embryonic hindlimb morphogenesis
GO:0044338	canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation
GO:0044339	canonical Wnt receptor signaling pathway involved in osteoblast differentiation
GO:0045165	cell fate commitment
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048697	positive regulation of collateral sprouting in absence of injury
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0060064	Spemann organizer formation at the anterior end of the primitive streak
GO:0060070	canonical Wnt signaling pathway
GO:0060173	limb development
GO:0060174	limb bud formation
GO:0060323	head morphogenesis
GO:0061180	mammary gland epithelium development
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0031012	extracellular matrix