Version 5.4
Homo sapiens Gene: USP30
Summary
InnateDB Gene IDBG-55703.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP30
Gene Name ubiquitin specific peptidase 30
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135093
Encoded Proteins
IDBP-55705
ubiquitin specific peptidase 30
IDBP-809178
ubiquitin specific peptidase 30
IDBP-244956
ubiquitin specific peptidase 30
IDBP-809180
ubiquitin specific peptidase 30
IDBP-591048
ubiquitin specific peptidase 30
IDBP-590627
ubiquitin specific peptidase 30
IDBP-594824
ubiquitin specific peptidase 30
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:109023089-109088026
Strand Forward strand
Band q24.11
Transcripts
ENST00000257548 ENSP00000257548
ENST00000377883 ENSP00000473942
ENST00000392784 ENSP00000376535
ENST00000467307
ENST00000479219
ENST00000491362
ENST00000470117 ENSP00000474166
ENST00000536723 ENSP00000443678
ENST00000536393 ENSP00000438829
ENST00000539121 ENSP00000440837
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0008234 cysteine-type peptidase activity
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0000422 mitochondrion degradation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008053 mitochondrial fusion
GO:0016579 protein deubiquitination
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029592
View Gene Order
ENSBTAG00000019845
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.486434
RefSeq NM_001301175 NM_032663 XM_005253962 XM_005253963 XM_005253965 XM_006719652 XM_006719653
HUGO
OMIM
CCDS CCDS9123
HPRD 15633
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca