Version 5.4
Homo sapiens Protein: USP30
Summary
InnateDB Protein IDBP-55705.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP30
Protein Name ubiquitin specific peptidase 30
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000257548
InnateDB Gene IDBG-55703 (USP30)
Protein Structure
UniProt Annotation
Function Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:24896179). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2. {ECO:0000269PubMed:18287522, ECO:0000269PubMed:24896179}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000269PubMed:18287522, ECO:0000269PubMed:24896179}.
Disease Associations
Tissue Specificity Expressed in skeletal muscle, pancreas, liver and kidney. {ECO:0000269PubMed:14715245}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0008234 cysteine-type peptidase activity
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0000422 mitochondrion degradation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008053 mitochondrial fusion
GO:0016579 protein deubiquitination
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
PFAM PF00443
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q70CQ3
PhosphoSite PhosphoSite-Q70CQ3
TrEMBL S4R3D1
UniProt Splice Variant
Entrez Gene 84749
UniGene Hs.486434
RefSeq NP_116052
HUGO HGNC:20065
OMIM 612492
CCDS CCDS9123
HPRD 15633
IMGT
EMBL AC011596 AJ586136 AK027820 AK097830 BC004868 BC022094 CH471054
GenPept AAH04868 AAH22094 BAB55392 BAG53537 CAE51936 EAW97842 EAW97844

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca