Version 5.4
Homo sapiens Gene: CLINT1
Summary
InnateDB Gene IDBG-55736.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLINT1
Gene Name clathrin interactor 1
Synonyms CLINT; ENTH; EPN4; EPNR
Species Homo sapiens
Ensembl Gene ENSG00000113282
Encoded Proteins
IDBP-380951
clathrin interactor 1
IDBP-484214
clathrin interactor 1
IDBP-480402
clathrin interactor 1
IDBP-588832
clathrin interactor 1
IDBP-583695
clathrin interactor 1
IDBP-602171
clathrin interactor 1
IDBP-595422
clathrin interactor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:157785743-157859175
Strand Reverse strand
Band q33.3
Transcripts
ENST00000411809 ENSP00000388340
ENST00000523094 ENSP00000429345
ENST00000524306
ENST00000518855
ENST00000523908 ENSP00000429824
ENST00000522381 ENSP00000434334
ENST00000521047 ENSP00000431858
ENST00000521615 ENSP00000433013
ENST00000530742 ENSP00000433419
ENST00000530302
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
Experimentally validated
Total 45 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008289 lipid binding
GO:0030276 clathrin binding
Biological Process
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006897 endocytosis
GO:0048268 clathrin coat assembly
GO:0061024 membrane organization
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0030136 clathrin-coated vesicle
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006169
View Gene Order
ENSBTAG00000016199
Not yet available
Pathways
NETPATH
REACTOME
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.644000 Hs.721175
RefSeq NM_001195555 NM_001195556 NM_014666
HUGO
OMIM
CCDS CCDS47330 CCDS56388 CCDS56389
HPRD 06273
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca