InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLINT1

Summary

InnateDB Protein

IDBP-480402.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLINT1

Protein Name

clathrin interactor 1

Synonyms

CLINT; ENTH; EPN4; EPNR;

Species

Homo sapiens

Ensembl Protein

ENSP00000429824

InnateDB Gene

IDBG-55736 (CLINT1)

Protein Structure

UniProt Annotation

Function

Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269PubMed:12429846, ECO:0000269PubMed:12538641}.

Subcellular Localization

Cytoplasm. Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Found throughout the cell, with the exception of the cell surface. Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the trans-Golgi network.

Disease Associations

Tissue Specificity

Ubiquitously expressed at low to intermediate levels. {ECO:0000269PubMed:12429846, ECO:0000269PubMed:12538641}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.

Experimentally validated
Total	45 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008289	lipid binding
GO:0030276	clathrin binding

Biological Process

GO:0006892	post-Golgi vesicle-mediated transport
GO:0006897	endocytosis
GO:0048268	clathrin coat assembly
GO:0061024	membrane organization

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016020	membrane
GO:0030136	clathrin-coated vesicle
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm