Version 5.4
Homo sapiens Gene: EHD1
Summary
InnateDB Gene IDBG-55744.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EHD1
Gene Name EH-domain containing 1
Synonyms H-PAST; HPAST1; PAST; PAST1
Species Homo sapiens
Ensembl Gene ENSG00000110047
Encoded Proteins
IDBP-55746
EH-domain containing 1
IDBP-55750
EH-domain containing 1
IDBP-377954
EH-domain containing 1
IDBP-377958
EH-domain containing 1
IDBP-377960
EH-domain containing 1
IDBP-377963
EH-domain containing 1
IDBP-377965
EH-domain containing 1
IDBP-812887
EH-domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. [provided by RefSeq, Jul 2008]
This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:64851642-64888296
Strand Reverse strand
Band q13.1
Transcripts
ENST00000359393 ENSP00000352354
ENST00000320631 ENSP00000320516
ENST00000421510 ENSP00000391429
ENST00000433803 ENSP00000404944
ENST00000455148 ENSP00000396273
ENST00000457202 ENSP00000399022
ENST00000411683 ENSP00000403830
ENST00000484846
ENST00000488711
ENST00000498472
ENST00000466015
ENST00000489379
ENST00000621096 ENSP00000479153
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 53 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0017137 Rab GTPase binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0007596 blood coagulation
GO:0010886 positive regulation of cholesterol storage
GO:0016197 endosomal transport
GO:0031175 neuron projection development
GO:0032456 endocytic recycling
GO:0034383 low-density lipoprotein particle clearance
GO:0042632 cholesterol homeostasis
GO:0051260 protein homooligomerization
GO:1901741 positive regulation of myoblast fusion
GO:1990090 cellular response to nerve growth factor stimulus
GO:2001137 positive regulation of endocytic recycling
Cellular Component
GO:0005768 endosome
GO:0005769 early endosome
GO:0005811 lipid particle
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030139 endocytic vesicle
GO:0031095 platelet dense tubular network membrane
GO:0031901 early endosome membrane
GO:0048471 perinuclear region of cytoplasm
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000024772
View Gene Order
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt Q9H4M9
TrEMBL A0A024R571 B2R5U3 C9IZH1 C9J2Z4 C9JC03 C9JDQ8 C9JIJ3
UniProt Splice Variant
Entrez Gene 10938
UniGene Hs.122280 Hs.741731
RefSeq NM_001282444 NM_001282445 NM_006795
HUGO HGNC:3242
OMIM 605888
CCDS CCDS73315 CCDS8084
HPRD
IMGT
EMBL AF001434 AF099011 AK097842 AK312316 AP001187 AY007161 BC104799 BC104825 CH471076
GenPept AAB81204 AAD45866 AAG02009 AAI04800 AAI04826 BAG35240 BAG53542 EAW74317 EAW74318 EAW74319 EAW74320 EAW74321
RNA Seq Atlas 10938

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca