Version 5.4
Homo sapiens Gene: UNG
Summary
InnateDB Gene IDBG-55760.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UNG
Gene Name uracil-DNA glycosylase
Synonyms DGU; HIGM4; HIGM5; UDG; UNG1; UNG15; UNG2
Species Homo sapiens
Ensembl Gene ENSG00000076248
Encoded Proteins
IDBP-55762
uracil-DNA glycosylase
IDBP-55764
uracil-DNA glycosylase
IDBP-382721
uracil-DNA glycosylase
IDBP-584405
uracil-DNA glycosylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:109097574-109110992
Strand Forward strand
Band q24.11
Transcripts
ENST00000242576 ENSP00000242576
ENST00000336865 ENSP00000337398
ENST00000446767 ENSP00000400287
ENST00000540158
ENST00000539287 ENSP00000440784
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 23 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004844 uracil DNA N-glycosylase activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0016032 viral process
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029591
View Gene Order
ENSBTAG00000019848
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05340
Primary immunodeficiency pathway
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt P13051
TrEMBL E5KTA5 E5KTA6 F5GYA2 Q68DM5
UniProt Splice Variant
Entrez Gene 7374
UniGene Hs.191334
RefSeq NM_003362 NM_080911
HUGO HGNC:12572
OMIM 191525
CCDS CCDS9124 CCDS9125
HPRD
IMGT
EMBL AC007637 AF526277 AK291341 AK313552 BC015205 BC050634 CH471054 CR749342 HQ206226 HQ206227 HQ206228 HQ206229 HQ206230 HQ206231 HQ206232 HQ206233 HQ206234 HQ206235 HQ206236 HQ206237 HQ206238 HQ206239 HQ206240 HQ206241 HQ206242 HQ206243 HQ206244 HQ206245 HQ206246 HQ206247 HQ206248 HQ206249 HQ206250 HQ206251 HQ206252 HQ206253 HQ206254 HQ206255 HQ206256 HQ206257 HQ206258 HQ206259 HQ206260 HQ206261 HQ206262 HQ206263 HQ206264 HQ206265 X15653 X89398 Y09008
GenPept AAH15205 AAH50634 AAM77695 ADP92134 ADP92135 ADP92136 ADP92137 ADP92138 ADP92139 ADP92140 ADP92141 ADP92142 ADP92143 ADP92144 ADP92145 ADP92146 ADP92147 ADP92148 ADP92149 ADP92150 ADP92151 ADP92152 ADP92153 ADP92154 ADP92155 ADP92156 ADP92157 ADP92158 ADP92159 ADP92160 ADP92161 ADP92162 ADP92163 ADP92164 ADP92165 ADP92166 ADP92167 ADP92168 ADP92169 ADP92170 ADP92171 ADP92172 ADP92173 ADP92174 ADP92175 ADP92176 ADP92177 ADP92178 ADP92179 ADP92180 ADP92181 ADP92182 ADP92183 ADP92184 ADP92185 ADP92186 ADP92187 ADP92188 ADP92189 ADP92190 ADP92191 ADP92192 ADP92193 ADP92194 ADP92195 ADP92196 ADP92197 ADP92198 ADP92199 ADP92200 ADP92201 ADP92202 ADP92203 ADP92204 ADP92205 ADP92206 ADP92207 ADP92208 ADP92209 ADP92210 ADP92211 ADP92212 ADP92213 BAF84030 BAG36328 CAA33679 CAA61578 CAA61579 CAA70211 CAH18195 EAW97846 EAW97847 EAW97848 EAW97849 EAW97850
RNA Seq Atlas 7374

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca