Version 5.4
Mus musculus Gene: Ung
Summary
InnateDB Gene IDBG-192232.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ung
Gene Name uracil DNA glycosylase
Synonyms UNG1; UNG2
Species Mus musculus
Ensembl Gene ENSMUSG00000029591
Encoded Proteins
IDBP-192234
uracil DNA glycosylase
IDBP-192236
uracil DNA glycosylase
IDBP-256352
uracil DNA glycosylase
IDBP-533165
uracil DNA glycosylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076248:
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:114130386-114139323
Strand Forward strand
Band F
Transcripts
ENSMUST00000031587 ENSMUSP00000031587
ENSMUST00000102584 ENSMUSP00000099644
ENSMUST00000112275 ENSMUSP00000107894
ENSMUST00000143455
ENSMUST00000137402 ENSMUSP00000114140
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004844 uracil DNA N-glycosylase activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000076248
View Gene Order
ENSBTAG00000019848
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03410
Base excision repair pathway
mmu05340
Primary immunodeficiency pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05340
Primary immunodeficiency pathway
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3Z1G1
UniProt Splice Variant
Entrez Gene 22256
UniGene Mm.1393
RefSeq NM_001040691 NM_011677
OMIM
CCDS CCDS19560 CCDS39221
HPRD
IMGT
MGI ID MGI:109352
MGI Symbol Ung
EMBL AC122282 AC129080
GenPept
RNA Seq Atlas 22256

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca