InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYBB

Summary

InnateDB Gene

IDBG-55775.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYBB

Gene Name

cytochrome b-245, beta polypeptide

Synonyms

AMCBX2; CGD; GP91-1; GP91-PHOX; GP91PHOX; IMD34; NOX2; p91-PHOX

Species

Homo sapiens

Ensembl Gene

ENSG00000165168

Encoded Proteins

IDBP-55777

cytochrome b-245, beta polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20421951

CYBB (NOX2) functions in reactive oxygen species (ROS) generation to induce TNF-alpha-mediated host cell apoptosis and it function in sensing of persistent intracellular pathogens for subsequent induction of host cell apoptosis as a second line of defence.

PMID 19339495

CYBB is an NADPH oxidases which plays a central role in microbial killing by phagocytes through the generation of reactive oxygen species (ROS) and CYBB-generated ROS are necessary for LC3 recruitment to phagosomes, coupling oxidative and non-oxidative killing activities of the CYBB NADPH oxidase in phagocytes through autophagy.

PMID 20532218

CYBB and reactive oxygen species (ROS) are required for the host cell to trigger an efficient RIG-I-mediated IRF-3 activation and downstream antiviral IFNbeta and IFIT1 gene expression and CYBB is critical for the expression of the central mitochondria-associated adaptor MAVS.

Entrez Gene

Summary

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell\'s respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:37780011-37813461

Strand

Forward strand

Band

p21.1

Transcripts

ENST00000378588	ENSP00000367851
ENST00000492288

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	13 [view]
Protein-DNA	14 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005244	voltage-gated ion channel activity
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006801	superoxide metabolic process
GO:0006811	ion transport
GO:0006954	inflammatory response
GO:0007584	response to nutrient
GO:0034765	regulation of ion transmembrane transport
GO:0042493	response to drug
GO:0042554	superoxide anion generation
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045087	innate immune response (InnateDB)
GO:0045730	respiratory burst
GO:0050665	hydrogen peroxide biosynthetic process
GO:0051701	interaction with host
GO:0055114	oxidation-reduction process
GO:0090382	phagosome maturation

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0030425	dendrite
GO:0030670	phagocytic vesicle membrane
GO:0043020	NADPH oxidase complex
GO:0043025	neuronal cell body