InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cybb

Summary

InnateDB Gene

IDBG-131158.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cybb

Gene Name

cytochrome b-245, beta polypeptide

Synonyms

C88302; Cgd; CGD91-phox; Cyd; gp91-1; gp91phox; Nox2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015340

Encoded Proteins

IDBP-131160

cytochrome b-245, beta polypeptide

IDBP-622217

cytochrome b-245, beta polypeptide

IDBP-622219

cytochrome b-245, beta polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20421951

[Homo sapiens] CYBB (NOX2) functions in reactive oxygen species (ROS) generation to induce TNF-alpha-mediated host cell apoptosis and it function in sensing of persistent intracellular pathogens for subsequent induction of host cell apoptosis as a second line of defence.

PMID 19339495

[Homo sapiens] CYBB is an NADPH oxidases which plays a central role in microbial killing by phagocytes through the generation of reactive oxygen species (ROS) and CYBB-generated ROS are necessary for LC3 recruitment to phagosomes, coupling oxidative and non-oxidative killing activities of the CYBB NADPH oxidase in phagocytes through autophagy.

PMID 20532218

[Homo sapiens] CYBB and reactive oxygen species (ROS) are required for the host cell to trigger an efficient RIG-I-mediated IRF-3 activation and downstream antiviral IFNbeta and IFIT1 gene expression and CYBB is critical for the expression of the central mitochondria-associated adaptor MAVS.

Entrez Gene

Summary

This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of reactive oxygen species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:9435252-9487771

Strand

Reverse strand

Band

A1.1

Transcripts

ENSMUST00000015484	ENSMUSP00000015484
ENSMUST00000154503
ENSMUST00000131591
ENSMUST00000164685	ENSMUSP00000128963
ENSMUST00000170885	ENSMUSP00000128993

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005244	voltage-gated ion channel activity
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006801	superoxide metabolic process
GO:0006811	ion transport
GO:0006954	inflammatory response
GO:0007584	response to nutrient
GO:0034765	regulation of ion transmembrane transport
GO:0042493	response to drug
GO:0042554	superoxide anion generation
GO:0050665	hydrogen peroxide biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0030425	dendrite
GO:0043020	NADPH oxidase complex
GO:0043025	neuronal cell body