Homo sapiens Gene: MYL4

Summary
InnateDB Gene IDBG-55861.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol MYL4
Gene Name myosin, light chain 4, alkali; atrial, embryonic
Synonyms ALC1; AMLC; GT1
Species Homo sapiens
Ensembl Gene ENSG00000198336
Encoded Proteins
IDBP-55863 myosin, light chain 4, alkali; atrial, embryonic
IDBP-243608 myosin, light chain 4, alkali; atrial, embryonic
IDBP-589613 myosin, light chain 4, alkali; atrial, embryonic
IDBP-762732
IDBP-760397
IDBP-760140
IDBP-763896
IDBP-762238
IDBP-763264
IDBP-758980
Entrez Gene
Summary Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17: 45277812-45301045
Strand Forward strand
Band q21.32
Transcripts
ENST00000354968  ENSP00000347055
ENST00000393450  ENSP00000377096
ENST00000536623  ENSP00000442375
ENST00000572303  ENSP00000461747
ENST00000570772  ENSP00000458194
ENST00000571981  ENSP00000459035
ENST00000576874  ENSP00000458907
ENST00000572316  ENSP00000461570
ENST00000573747  ENSP00000460734
ENST00000570671  ENSP00000461121
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein‑Protein  2
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003785 actin monomer binding
GO:0005509 calcium ion binding
GO:0008307 structural constituent of muscle
GO:0032038 myosin II heavy chain binding
GO:0051015 actin filament binding
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0007517 muscle organ development
GO:0030049 muscle filament sliding
GO:0032781 positive regulation of ATPase activity
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005829 cytosol
GO:0005859 muscle myosin complex
GO:0031672 A band
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000061086 Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000021916 Not yet available Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
REACT_16969 Striated Muscle Contraction
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P12829 
TrEMBL I3L1K6 I3L1R3 I3L3U1 I3L532
UniProt Splice Variant
Entrez Gene 4635 
UniGene Hs.463300
RefSeq NM_001002841  NM_002476 
HUGO 7585 
OMIM 160770
CCDS CCDS11510 
HPRD 01176
IMGT
EMBL AC068234 AC087649 AF116676 BC030228 CH471231 M20641 M24121 M36172 M37069 M37070 M37071 M37072 M37073 M37074 X13955 X58851 X58852 X58853 X58854
GenPept AAA36319  AAA59856  AAA59858  AAA59891  AAF71096  AAH30228  CAA32137  CAA41655  EAW57684  EAW57685 
ImmGen MYL4 (murine) 
RNA Seq Atlas 4635