Homo sapiens Gene: MYL4
Summary
InnateDB Gene IDBG-55861.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYL4
Gene Name myosin, light chain 4, alkali; atrial, embryonic
Synonyms ALC1; AMLC; GT1;
Species Homo sapiens
Ensembl Gene ENSG00000198336
Encoded Proteins
myosin, light chain 4, alkali; atrial, embryonic
myosin, light chain 4, alkali; atrial, embryonic
myosin, light chain 4, alkali; atrial, embryonic
Protein Structure
Entrez Gene
Summary Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:47200446-47223679
Strand Forward strand
Band q21.32
Transcripts
ENST00000354968 ENSP00000347055
ENST00000393450 ENSP00000377096
ENST00000536623 ENSP00000442375
ENST00000572303 ENSP00000461747
ENST00000570772 ENSP00000458194
ENST00000571981 ENSP00000459035
ENST00000576874 ENSP00000458907
ENST00000572316 ENSP00000461570
ENST00000573747 ENSP00000460734
ENST00000570671 ENSP00000461121
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003785 actin monomer binding
GO:0005509 calcium ion binding
GO:0032038 myosin II heavy chain binding
GO:0051015 actin filament binding
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0030049 muscle filament sliding
GO:0032781 positive regulation of ATPase activity
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005829 cytosol
GO:0016459 myosin complex
GO:0031672 A band
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Muscle contraction pathway
Striated Muscle Contraction pathway
KEGG
Cardiac muscle contraction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P12829
TrEMBL I3L1K6 I3L1R3 I3L3U1 I3L532
UniProt Splice Variant
Entrez Gene 4635
UniGene Hs.463300
RefSeq NM_001002841 NM_002476 XM_005257391 XM_005257392
HUGO HGNC:7585
OMIM 160770
CCDS CCDS11510
HPRD 01176
IMGT
EMBL AC068234 AC087649 AF116676 BC030228 CH471231 M20641 M24121 M36172 M37069 M37070 M37071 M37072 M37073 M37074 X13955 X58851 X58852 X58853 X58854
GenPept AAA36319 AAA59856 AAA59858 AAA59891 AAF71096 AAH30228 CAA32137 CAA41655 EAW57684 EAW57685
ImmGen MYL4 (murine)
RNA Seq Atlas 4635