Version 5.4
Homo sapiens Gene: MYL4
Summary
InnateDB Gene IDBG-55861.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYL4
Gene Name myosin, light chain 4, alkali; atrial, embryonic
Synonyms ALC1; AMLC; GT1
Species Homo sapiens
Ensembl Gene ENSG00000198336
Encoded Proteins
IDBP-55863
myosin, light chain 4, alkali; atrial, embryonic
IDBP-243608
myosin, light chain 4, alkali; atrial, embryonic
IDBP-589613
myosin, light chain 4, alkali; atrial, embryonic
IDBP-762732
IDBP-760397
IDBP-760140
IDBP-763896
IDBP-762238
IDBP-763264
IDBP-758980
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:47200446-47223679
Strand Forward strand
Band q21.32
Transcripts
ENST00000354968 ENSP00000347055
ENST00000393450 ENSP00000377096
ENST00000536623 ENSP00000442375
ENST00000572303 ENSP00000461747
ENST00000570772 ENSP00000458194
ENST00000571981 ENSP00000459035
ENST00000576874 ENSP00000458907
ENST00000572316 ENSP00000461570
ENST00000573747 ENSP00000460734
ENST00000570671 ENSP00000461121
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003785 actin monomer binding
GO:0005509 calcium ion binding
GO:0032038 myosin II heavy chain binding
GO:0051015 actin filament binding
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0030049 muscle filament sliding
GO:0032781 positive regulation of ATPase activity
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005829 cytosol
GO:0016459 myosin complex
GO:0031672 A band
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061086
View Gene Order
ENSBTAG00000021916
Not yet available
Pathways
NETPATH
REACTOME
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa04260
Cardiac muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.463300
RefSeq NM_001002841 NM_002476 XM_005257391 XM_005257392
HUGO
OMIM
CCDS CCDS11510
HPRD 01176
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca